Tag

Thermogenesis

All articles tagged with #thermogenesis

SLIT3 Wiring in Brown Fat Boosts Calorie Burning and Heat Production
science17 days ago

SLIT3 Wiring in Brown Fat Boosts Calorie Burning and Heat Production

A Nature Communications study reveals brown fat uses SLIT3 fragments, produced by BMP1, to drive blood vessel and nerve growth essential for thermogenesis. In mice, removing SLIT3 or its receptor PLXNA1 impairs nerve and vascular networks and lowers heat production, while human fat analyses suggest SLIT3 activity may influence obesity and insulin sensitivity, pointing to therapies that increase energy expenditure rather than curb appetite.

Low Methionine and Cysteine Diet Sparks Fat Burning in Mice
health-and-medicine1 month ago

Low Methionine and Cysteine Diet Sparks Fat Burning in Mice

Reducing two amino acids common in animal protein—methionine and cysteine—in mice boosted energy expenditure by about 20% via beige fat, causing weight loss without changing food intake or activity, and was comparable to constant cold exposure, suggesting diet alone could activate fat-burning pathways, though human relevance remains unproven and further work on safety and applicability is needed.

Do Cold Temperatures Boost Calorie Burn? Experts Explain
health-and-fitness3 months ago

Do Cold Temperatures Boost Calorie Burn? Experts Explain

Exposing your body to cold weather can increase calorie burn through shivering and non-shivering thermogenesis, especially below 60-66°F, but factors like wind chill, clothing, and body composition influence the effect. While outdoor cold workouts offer a slight metabolic boost, proper clothing and gradual acclimation are essential for safety and effectiveness.

Unveiling the Power of GDF15: A Breakthrough in Obesity and Diabetes Treatment
health-and-science2 years ago

Unveiling the Power of GDF15: A Breakthrough in Obesity and Diabetes Treatment

Scientists have used a cryogenic electron microscope to unveil the atomic structure of UCP1, a protein found in "good" brown fat that plays a key role in calorie burning and thermogenesis. This breakthrough offers insights into potential treatments for obesity and diabetes by harnessing the activity of UCP1 in brown fat cells to promote weight loss and regulate glucose levels. The research provides the first detailed understanding of UCP1 and its potential for combating obesity and controlling diabetes.