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Type 1 Diabetes

All articles tagged with #type 1 diabetes

Early Trial Shows Type 1 Diabetics Can Stop Insulin Using New Anti-Rejection Drug
health15 days ago

Early Trial Shows Type 1 Diabetics Can Stop Insulin Using New Anti-Rejection Drug

An early-stage clinical trial has demonstrated that individuals with Type 1 diabetes can discontinue insulin therapy after receiving an experimental medication designed to prevent organ transplant rejection. The treatment aims to restore natural insulin production by suppressing the immune system's attack on pancreatic beta cells, offering a potential functional cure rather than just management. While experts express cautious optimism regarding the initial results, they emphasize that further research is required to confirm long-term safety and efficacy before widespread adoption.

via NBC News|
#clinical-trials#health#immunology
Early gut microbiome stagnation triples type 1 diabetes risk in genetically susceptible children
health28 days ago

Early gut microbiome stagnation triples type 1 diabetes risk in genetically susceptible children

A new study in Nature Metabolism reveals that the trajectory of gut microbiome development in early childhood interacts with host genetics to predict type 1 diabetes (T1D) risk. Analyzing 887 high-risk children, researchers identified a specific 'Early Plateaued' microbiome pattern associated with a threefold increased risk of T1D. This risk is further modified by genetic variants related to immune responses, highlighting a critical window for early microbial exposure and genetic interplay in disease susceptibility.

via Nature|
#bifidobacterium#gut-microbiome#health
health2 months ago

Turmeric Compound Protects Blood Vessels in Diabetic Rats

Researchers at Florida Institute of Technology found that curcumin, the active compound in turmeric, improved blood vessel health in rats with Type 1 diabetes. The study, presented at the 2026 American Physiology Summit, showed that curcumin reduced inflammation and restored normal calcium activity in the aorta. While these results suggest potential benefits for cardiovascular complications associated with diabetes, the findings are based on animal models and require human clinical trials to determine safety and efficacy.

via SciTechDaily|
#cardiovascular-health#curcumin#health
Mapping early β‑cell changes and immune interactions in type 1 diabetes progression
science3 months ago

Mapping early β‑cell changes and immune interactions in type 1 diabetes progression

A large-scale imaging mass cytometry study of 88 human pancreata across the type 1 diabetes spectrum profiles 16 million cells to map β-cell states and the islet–immune interface. It finds β-cells show IAPP loss in preclinical stages and increased MHC-I at onset, with no universal rise in selected ER-stress markers. Insulitic islets display IFN signatures. Early disease features include pro‑inflammatory M1/M2‑like macrophages and exhausted‑like PD1+ TIM3+ T cells whose interactions occur at the islet edge and within islets, suggesting antigen presentation and regulatory dynamics. Age-related motifs reveal more TLS-like B/T cell structures and CD11c+ macrophages in younger donors. Pseudotime analysis suggests a single trajectory from healthy to insulitic β-cells, driven by macrophage–DC–exhausted T cell axis as disease progresses. The work provides a rich resource for understanding early T1D progression and identifying potential therapeutic targets and biomarkers.

via Nature|
#b-cells#imaging-mass-cytometry#insulitis
Autologous CiPSC Islet Transplant Brings Insulin Independence to Type 1 Diabetes Patient
science3 months ago

Autologous CiPSC Islet Transplant Brings Insulin Independence to Type 1 Diabetes Patient

A 25-year-old woman with lifelong Type 1 diabetes received an autologous transplant of chemically induced pluripotent stem cell–derived pancreatic islet cells, transplanted into the abdominal wall in 2023. Within 75 days she stopped needing insulin and achieved non-diabetic HbA1c with over 98% time in range, marking a first proof-of-concept for patient-derived islet cells. However, the result comes from a single case with prior immunosuppression from a liver transplant, and durability and broader applicability require more patients and longer follow-up.

via Space Daily|
#autologous-transplant#cipsc#insulin-independence
NHS rolls out teplizumab to delay the onset of type 1 diabetes
health3 months ago

NHS rolls out teplizumab to delay the onset of type 1 diabetes

England and Wales will offer teplizumab, the first treatment shown to delay onset of type 1 diabetes by around three years, given as 14 days of IV infusions before symptoms. NICE estimates about 1,100 adults and children could be eligible in the first year, with a confidential NHS discount on the roughly £150,000-per-course price. The drug requires evidence of pre-symptomatic immune attack on the pancreas; routine UK screening remains unavailable. Scotland and Northern Ireland have separate processes, with Scotland’s SMC expected to issue advice in 2027.

via BBC|
#health#immunotherapy#nhs
Century-old TB vaccine lowers insulin needs in autoimmune diabetes (trial)
health4 months ago

Century-old TB vaccine lowers insulin needs in autoimmune diabetes (trial)

A phase II trial found that the century-old Bacillus Calmette–Guérin (BCG) vaccine reduced insulin requirements in people with autoimmune diabetes (LADA and juvenile-onset type 1), with treated participants using about 3% less insulin over five years vs. a 22% increase in the placebo group, suggesting immune activation by BCG can slow beta-cell deterioration and improve blood-sugar management.

via Nature|
#autoimmunity#bcg-vaccine#diabetes
Artemis II returns, kakapo thrives, and Shroud DNA surprises
science6 months ago

Artemis II returns, kakapo thrives, and Shroud DNA surprises

Artemis II completes its lunar flyby with a record-setting Pacific splashdown, while New Zealand’s kakapo marks a major breeding season as part of its recovery effort. In archaeology/ancient DNA news, the Shroud of Turin DNA analysis reveals human and non-human DNA (including carrots and red coral), fueling ongoing debate about its origin. The week also highlights progress toward a functional cure for type 1 diabetes in a Science Spotlight.

via Live Science|
#artemis-ii#dna-analysis#kakapo
Budget-Friendly Metformin Cuts Insulin Dose in Type 1 Diabetes, Trial Shows
health7 months ago

Budget-Friendly Metformin Cuts Insulin Dose in Type 1 Diabetes, Trial Shows

A 26-week randomized trial (INTIMET) in 40 adults with long-standing type 1 diabetes found metformin did not improve insulin resistance or glucose control, but reduced total daily insulin requirements by about 12% compared with placebo, suggesting metformin may ease the insulin burden rather than reverse insulin resistance; researchers are exploring whether gut microbiome interactions explain the effect.

via SciTechDaily|
#clinical-trial#health#insulin-reduction
Hybrid Immune Transplants Reverse Type 1 Diabetes in Mice
health7 months ago

Hybrid Immune Transplants Reverse Type 1 Diabetes in Mice

Stanford researchers show that in mice, a combined transplant of donor blood stem cells and mismatched pancreatic islet cells can restore insulin production and retrain the immune system, curing or preventing autoimmune Type 1 diabetes without immunosuppressants or graft-versus-host disease for at least six months, using CD117 antibody–based conditioning to create a hybrid immune system and a path toward human translation (with challenges like donor islet availability).

via SciTechDaily|
#graft-versus-host-disease#health#immune-system-reset
Understanding and Recognizing Childhood Type 1 Diabetes
health11 months ago

Understanding and Recognizing Childhood Type 1 Diabetes

Scientists have discovered that type 1 diabetes is more severe in young children because their developing pancreas has smaller, more vulnerable beta cell clusters that are more easily destroyed by the immune system. This finding could lead to new treatments, including immunotherapy drugs like teplizumab, which may delay or prevent the disease in children.

via BBC|
#beta-cells#children#health