Tag

Mutations

All articles tagged with #mutations

science1 month ago•6 min saved

DeepMind maps every possible DNA-letter mutation in the human genome

DeepMind releases the AlphaGenome Atlas, predicting the consequences of all 9 billion single-letter DNA mutations across the human genome with the AlphaGenome AI, including a single-score AVI to flag disease-causing changes; the atlas helps explore noncoding regions and DNA motifs, potentially aiding rare-disease diagnosis and biological insight, but does not replace experiments and clinical context. The data set (~1 petabyte) is freely available for non-commercial use via an API, lowering computational barriers and accelerating research.

via Nature|

#ai #alphagenome #deepmind

genomics1 month ago•5 min saved

Rewriting a virus genome exposes AI’s blind spots in biology

A Nature study mutated almost every nucleotide of phage ΦX174, generating over 44,000 variants and assessing their fitness in E. coli. Most single-nucleotide changes were harmful, with AI models struggling to predict these effects, underscoring the need for more experimental data to train biology-focused AI and revealing the current limits of AI in genome design.

via Nature|

#artificial-intelligence #genomics #mutations

science2 months ago•11 min saved

Two Nearby Chernobyl Dog Populations Split Genetically, Yet Radiation-Driven Mutations Aren’t the Cause

A study of 302 free-roaming Chernobyl dogs found two genetically distinct groups only 16 kilometers apart; a follow-up investigation found no evidence that radiation exposure increased mutation rates to explain the split, suggesting population history, limited gene flow, or selection as possible drivers.

via Space Daily|

#chernobyl #dogs #genetics

science3 months ago•4 min saved

New York City's Mice Evolve Against Common Poisons, Rutgers Study Finds

Rutgers researchers analyzing rodent samples from New York City, the Washington, D.C. area, New Jersey and Philadelphia found that about 70% of mouse populations carry genetic mutations linked to resistance to commonly used rodenticides, suggesting rapid evolution that could undermine extermination efforts; while rats are adapting too, the study urges cities to shift toward prevention and sanitation (reducing food sources and improving trash management) and notes that developing new pesticides would take years, underscoring the need to preserve the effectiveness of existing products.

via ABC7 New York|

#mice #mutations #new-york-city

science3 months ago•2 min saved

Rutgers study: Philadelphia mice mutating, forcing changes in pest control

A Rutgers University study of rodent samples from the Philadelphia region found that about 70% of mice carry mutations that help them survive poisons, while rats are also evolving to dodge traps, suggesting pest-control strategies must shift toward prevention and sanitation while new chemical formulations are developed over years.

via 6abc Philadelphia|

#mice #mutations #pest-control

science6 months ago•3 min saved

Cloning Limit Exposed: Mouse Line Dies After 58 Generations

A two-decade Japanese study recloned a female mouse across 58 generations. By generation 58, all offspring died within a day of birth, with no outward defects, and DNA analysis showed accumulating mutations and occasional loss of an X chromosome. The research indicates a hard limit to mammalian cloning and challenges hopes for infinite lineages, with implications for livestock cloning and de-extinction efforts; no method yet exists to overcome this genetic deterioration.

via Futurism|

#cloning #dna #genetics

science6 months ago•3 min saved

Mammals Cloned Across 58 Generations Collapse, Study Finds

A 20-year experiment cloning over 1,200 mice across 58 generations shows that deleterious genetic mutations accumulate in cloned lineages, with the 58th generation dying shortly after birth. Initial generations appeared healthy, but the line ultimately collapsed, confirming that mammalian cloning cannot sustain long-term viability and that sexual reproduction is essential for species survival; researchers call for advances in nuclear transfer techniques.

via Ground News|

#cloning #genetics #mullers-ratchet

health6 months ago•20 min saved

Cicada: Highly Mutated COVID-19 Variant BA.3.2 Tracked as Potential Surge Trigger

Public health authorities are monitoring BA.3.2, nicknamed Cicada, a highly mutated COVID-19 variant with up to 70–75 mutations detected in the U.S. and in 22 other countries. Current U.S. levels are very low (~0.19% of sequences), but the variant has spread internationally and may evade vaccine- or prior-infection–induced antibodies, potentially weakening protection against infection though vaccines are still expected to guard against severe disease. Experts caution Cicada could drive a summer surge if it spreads more efficiently, but it is not yet dominant, underscoring the need for ongoing genomic surveillance and vaccination.

via Everyday Health|

#covid-19 #health #mutations

science6 months ago•6 min saved

Mouse cloning hits a genetic ceiling after 58 generations

Two decades, 58 generations and more than 30,000 cloning attempts show a single mouse cannot be serially recloned indefinitely: harmful DNA changes accumulate in the lineage, including chromosome losses, leading to a failure of later attempts and suggesting genome instability makes mammalian cloning unsustainable and potentially limits its use in agriculture and vertebrate breeding.

via Nature|

#cloning #genetics #mice

science6 months ago•4 min saved

Cloning's mutational cliff: line ends after 58 generations

A Japanese team conducted a serial cloning study starting from one female mouse, re-cloning for 57 generations and producing over 1,200 offspring. By generation 58, accumulated genetic mutations and loss of the X chromosome caused the re-cloned mice to die shortly after birth, effectively ending the line. Crossbreeding later-generation clones with normal mice showed initially normal litter sizes but reduced fertility in later-generation lines, with partial recovery in descendants. The results support Muller's ratchet and reinforce the idea that sexual reproduction is essential for long-term mammalian survival, limiting the practical viability of endless cloning.

via ScienceAlert|

#genetic-cloning #mammals #mullers-ratchet

biology6 months ago•16 min saved

Clone-ception Hits a Wall: Infinite Cloning Isn’t Feasible

Japanese researchers studying serial cloning in mice with the epigenetic modifier trichostatin A found that while many late-generation clones were healthy at birth, the lineage eventually hit a hard limit: by the 58th generation the clones survived for only a day. TSA boosted cloning success (about 5.4% at generation 51) compared with 1.6% without it, and over 1,200 clones were produced from a single donor. Each generation accumulated mutations (roughly 70 SNVs and 1.5 structural variants), and in some cases placental abnormalities were corrected in later offspring through sexual reproduction, suggesting that sexual reproduction helps purge deleterious mutations and that indefinite cloning remains biologically unfeasible for now.

via Gizmodo|

#biology #cloning #epigenetics

gaming8 months ago•13 min saved

Mewgenics Delivers Deep, Cat-Centered Roguelite Chaos

Mewgenics blends base-building cat breeding with tactical, turn-based dungeon combat across interconnected acts, rewarding experimentation with hybrid classes and mutations while delivering irreverent humor and a distinctive Isaac-inspired aesthetic; the depth is staggering and highly addictive, though newcomers may feel overwhelmed by its systems, limited early information on breeding and items, and the sheer randomness that can both empower and derail runs.

via GameSpot|

#cat-breeding #gaming #mewgenics

science8 months ago•19 min saved

AlphaGenome: DeepMind’s AI Maps the Genome’s Hidden Rules

DeepMind’s AlphaGenome trains an AI on vast molecular data to forecast how mutations and regulatory DNA elements alter gene activity, extending the AlphaFold-era breakthrough from proteins to the genome; experts see it as a major engineering advance with potential for cancer and disease research, but stress it remains a predictive tool—its scope is limited to single mutations in a given genome, its predictions don’t capture all splice-site complexities, and clinical use still requires lab validation.

via The New York Times|

#artificial-intelligence #dna #gene-regulation

science9 months ago•6 min saved

Rapid Mutations in Aging Sperm Surprise Scientists

New research shows that harmful genetic mutations in sperm increase with age and are actively favored during sperm production, raising genetic risks for offspring as men grow older, with some mutations linked to serious diseases and cancer, and evidence of natural selection within the testes influencing mutation rates.

via SciTechDaily|

#aging #genetic-risk #mutations

science11 months ago•2 min saved

Older Men's Sperm Have More Mutations, Potentially Harmful

Research shows that as men age, their sperm accumulate more mutations, some of which are harmful and linked to developmental disorders and cancers, increasing the potential health risks for their children. The study highlights the role of 'selfish' mutations that outcompete others in the testes, with mutation rates rising from 2% in men in their 30s to about 4.5% in men over 70, though not all mutations are necessarily passed on or harmful. Further research is needed to understand the full impact on offspring health.

via ScienceAlert|

#aging #disease-risk #genetics