Tag

Telomeres

All articles tagged with #telomeres

science7 days ago•13 min saved

Spaceflight Leaves Lasting Molecular Footprints, Twin Study Reveals

NASA’s Scott–Mark Kelly twin study found no DNA sequence changes from a 340‑day mission, but about 7% of Scott’s gene expression remained dysregulated six months after landing. Telomeres lengthened in space and then shortened to below baseline upon return. Cognitive performance stayed slower for months; immune function, DNA repair, bone formation, hypoxia response, and mitochondrial pathways were affected, and liver metabolism shifted, suggesting spaceflight perturbs an interconnected biological network with lasting effects for future long-duration missions.

via Space Daily|

#gene-expression #mitochondria #science

science10 days ago•5 min saved

Melanoma Telomere Trick: Dual Mutations Drive Immortality

Researchers uncovered a two-part genetic strategy used by melanoma cells to bypass cellular aging: mutations that boost telomerase production via TERT and concurrent promoter mutations in ACD that recruit telomerase to telomeres through the shelterin component TPP1, lengthening chromosome caps and enabling extended cell division. This explains the unusually long telomeres seen in melanoma and points to a potential new therapeutic target.

via SciTechDaily|

#melanoma #science #telomerase

science16 days ago•6 min saved

Underwater 100-Day Experiment Sparks Aging-Reversal Claims

Biomedical engineer Joseph Dituri spent 100 days in a 22-foot-deep underwater habitat at 1.6 ATA, undergoing tests that found increased energy, lower cholesterol and inflammatory markers, and a sevenfold rise in testosterone, plus REM sleep gains and a temporary height loss from pressure. He argues daily hyperbaric oxygen therapy could shave 10 years off age, but scientists caution there is no robust evidence that such exposure extends life expectancy and some findings were misinterpreted. Dituri is now part of a larger 200-participant XPRIZE effort to study healthy lifespan extension.

via Indian Defence Review|

#aging #hyperbaric-oxygen-therapy #science

lifestyle1 month ago•18 min saved

Dark chocolate’s theobromine linked to slower aging in humans

A study of about 1,600 adults found higher blood levels of theobromine, a compound in cocoa, linked to slower biological aging markers—lower GrimAge acceleration and longer telomeres. The association persisted after adjusting for age, weight, smoking, and even caffeine, and appeared strongest among former smokers. The work is observational, so it cannot prove causation, and researchers emphasize diet quality over chasing a single nutrient. They note the potential that theobromine enhances cocoa’s polyphenols, and call for controlled trials to determine causality and practical guidance on dark‑chocolate consumption.

via Earth.com|

#aging #dark-chocolate #epigenetics

science2 months ago•7 min saved

Dick Van Dyke Turns 100, Crediting a Calm Outlook—And Science Seems to Agree

Dick Van Dyke recently turned 100 and attributes his longevity to a positive outlook and never getting angry; research cited alongside the piece links optimism and stress reduction to longer lifespans, discusses telomeres as a cellular aging factor, and notes that better anger management and healthy habits may contribute to longer, healthier aging.

via ScienceAlert|

#anger-management #dick-van-dyke #longevity

lifestyle2 months ago•17 min saved

Theobromine in chocolate could slow aging, study suggests

A King's College London study found higher blood theobromine levels, a compound in dark chocolate and coffee, are linked to slower biological aging markers (GrimAge and DNAmTL) in about 1,600 adults, even after accounting for caffeine; the signal is strongest among former-smokers and appears independent of caffeine. However, the study is observational and cannot prove causation, so researchers advocate focusing on overall diet quality rather than chasing a single nutrient, while noting dark chocolate’s sugar and fat content and the importance of modest portions.

via Earth.com|

#aging #chocolate #epigenetics

science2 months ago•5 min saved

DMTF1 could reboot aging brain cells, study finds

Researchers show that upregulating the neural stem cell protein DMTF1 reverses aging-related proliferation decline in neural stem cells, restoring their growth in human and mouse models via chromatin remodeling and telomere-related pathways—offering a framework for brain repair therapies, though the work is early-stage.

via Indian Defence Review|

#aging #chromatin-remodeling #dmtf1

science3 months ago•4 min saved

NASA Twin Study: Space Alters Gene Activity and Telomeres, Most Changes Rebound

NASA's twin study compared Scott Kelly in orbit with his Earthbound brother Mark to isolate space effects; researchers found rapid gene-expression shifts and heightened immune activity in Scott, with telomere elongation in space that shortened after return; radiation caused more DNA damage and repair signals in Scott than Mark; by six to eight months post-mission, most gene-expression changes had reverted, indicating reversibility but signaling potential long-term risks for future long-duration missions such as cardiovascular strain, vision problems, and cancer risk.

via supercarblondie.com|

#genetics #nasa #radiation

science3 months ago•7 min saved

DMTF1: A Molecular Switch to Rejuvenate Aging Brain Cells

Researchers have identified the transcription factor DMTF1 as a key regulator that preserves neural stem cell activity in aging brains. In aging models with telomere damage, DMTF1 levels drop and neural stem cell regeneration declines; reactivating DMTF1 restores regenerative capacity and reveals its role in activating helper genes that open chromatin for growth-related genes. This suggests potential therapies to slow cognitive aging by boosting neural stem cell function, though most work so far is in vitro, with the long-term aim of developing small molecules to safely enhance DMTF1 without increasing brain tumor risk.

via SciTechDaily|

#brain-aging #dmtf1 #neural-stem-cells

science3 months ago•6 min saved

Blood Theobromine Tied to Slower Biological Aging in European Cohorts

A large observational study across two European cohorts (TwinsUK and KORA) finds higher blood theobromine, a compound found in dark chocolate, cocoa, and coffee, is associated with slower biological aging—lower epigenetic age acceleration and longer telomeres—even after adjusting for caffeine and other factors. While the associations are strong, causality isn’t established, and researchers urge controlled trials before making dietary recommendations; the link was particularly notable in former smokers.

via Indian Defence Review|

#aging #chocolate #epigenetic-clock

health3 months ago•10 min saved

Move More, Live Longer: The Proven Longevity Workout

Experts say longevity comes from regular, well-balanced movement rather than quick fixes: aim 150–300 minutes of moderate or 75–150 minutes of vigorous exercise weekly, plus two strength sessions; exercise boosts mitochondria, improves insulin sensitivity, lowers chronic inflammation, and protects the brain, while too much can trigger harmful inflammation—the ‘Goldilocks zone.’ Track recovery with HRV or VO2 max, and prioritize sleep. Integrate daily activity (standing desks, active breaks, walking meetings), stay socially connected, and manage stress. A practical plan includes 3–4 cardio sessions (two short/high‑intensity, two longer), two strength sessions with a mix of compound moves (squats, lunges, push-ups, pulls, planks), and weekly yoga.

via GQ|

#aging #exercise #health

health4 months ago•4 min saved

Strength Training May Slow Cellular Aging, Study Finds

A study of 4,814 U.S. adults found that those who did at least 90 minutes of strength training per week had telomeres about 60 base pairs longer than non-participants, a change estimated to equal roughly 3.9 years of reduced biological aging. Strength training includes weightlifting and bodyweight exercises (calisthenics, suspension training). The authors caution that telomere length is influenced by lifestyle and health factors, and causality is not fully understood, but when paired with flexibility and cardio, regular resistance work supports a holistic approach to long-term wellness.

via Military.com|

#aging #fitness #health

health4 months ago•262 min saved

Strength Training Could Add Nearly Four Years to Your Life

A Prevention study of ~5,000 adults found that regular strength-training (about 90 minutes per week) is tied to longer telomeres and nearly four years of reduced biological aging, suggesting strength work can extend lifespan; experts advise starting with 2 short weekly sessions of bodyweight moves before adding weights.

via AOL.com|

#aging #fitness #health

health4 months ago•3 min saved

New Research Reveals Optimal Coffee Habits for Longevity and Heart Health

A study suggests that drinking three to four cups of coffee daily may slow biological aging by up to five years, potentially increasing lifespan, due to antioxidants and anti-inflammatory compounds in coffee that preserve telomere length, especially in individuals with severe mental illnesses, though moderation is advised due to possible side effects.

via Prevention|

#antioxidants #biological-aging #coffee

health4 months ago•7 min saved

The Impact of Coffee on Longevity and Heart Health

Recent studies suggest that moderate coffee consumption (3-4 cups daily) may promote longevity, reduce the risk of chronic diseases, and support healthy aging by protecting cellular health and potentially extending lifespan, especially in women and individuals with psychiatric disorders.

via Medical News Today|

#chronic-disease #coffee #health