Tag

Telomeres

All articles tagged with #telomeres

science1 month ago•5 min saved

A 117-Year-Old’s Cells Show Youthful Clocks Hidden in an Aging Body

Researchers studying Maria Branyas Morera, the oldest known person, found a paradox in her biology: her cells carried clear signs of aging (short telomeres, pro-inflammatory immune features, and clonal hematopoiesis) while epigenetic clocks suggested her cells were about 23 years younger than her chronological age. Her gut microbiome was rich in Bifidobacterium, a pattern associated with youth and possibly linked to yogurt consumption. The study suggests that longevity and disease resistance may be partly separable processes, but it’s based on a single individual and requires larger cohorts for validation.

via Futura, le média qui explore le monde|

#aging #epigenetics #longevity

health1 month ago•14 min saved

Early-life sugar reduction linked to lower cancer risk and slower aging, study finds

A large UK study using the end of sugar rationing as a natural experiment found that people born during rationing had lower rates of several cancers later in life and longer leukocyte telomeres—equating to about 2.2 fewer years of biological aging—suggesting early sugar exposure may influence long-term health and eating habits, though the study does not prove sugar directly causes cancer and guidelines still advocate limiting added sugars for young children.

via The Times of India|

#aging #cancer #early-life-nutrition

health-and-medicine1 month ago•7 min saved

Tiny childhood sugar exposure linked to healthier aging and lower cancer risk

Using Britain’s postwar sugar rationing as a natural experiment, researchers found that lower sugar exposure before age 2 is associated with a lower incidence of several cancers (notably a 69% reduction in liver cancer) and about 2.2 years slower biological aging, as well as healthier, lower-sugar diets in midlife, suggesting early-life sweetness exposure can influence health and taste preferences for decades.

via ScienceDaily|

#aging #cancer #early-life-nutrition

health1 month ago•8 min saved

Early-life sugar limits may curb cancer risk for decades, study suggests

A UK Biobank-based study leveraging the end of post-war sugar rationing finds that individuals exposed to sugar limits in the first 1,000 days of life had lower rates of several cancers (liver, rectal, lung, prostate and breast) in adulthood and longer leukocyte telomeres, implying slower biological aging. The researchers propose two pathways: a lasting biological imprint and enduring healthier dietary habits. Yet the study is observational with limitations (possible biases, non-representative sample) and does not justify extreme sugar restriction; rather, it supports moderating added sugar during pregnancy and early childhood.

via Fox News|

#cancer #early-life-diet #health

science1 month ago•5 min saved

WWII sugar limits linked to lower cancer risk and slower aging

A 1940s UK sugar rationing policy limited sugar intake during the first 1,000 days of life. In a UK Biobank study of 64,761 people born 1951–1956, those exposed to sugar restriction in early life had dramatically lower adult cancer incidence (liver 69% lower; prostate 52%; lung 41%; rectal 40%; breast 36%), longer telomeres equating to about 2.2 years less biological aging, and persisted healthier diets into adulthood. The study, published in PNAS (2026) by Chen Zhu and Weilong Zhang, is observational but uses the rationing cutoff to suggest causal links between early sugar exposure and cancer risk.

via ScienceAlert|

#cancer #nutrition #science

health2 months ago•12 min saved

Filtered Coffee Slows Biological Aging, Instant Coffee Speeds It Up, UK Biobank Data Show

A UK Biobank study of 49,414 adults found filtered coffee linked to slower biological aging (lower PhenoAgeAccel and KDM-BAAccel, higher rLTL), while instant coffee associated with faster aging (higher PhenoAgeAccel and KDM-BAAccel, lower rLTL). Effects are small and influenced by covariates like smoking, BMI, and dairy/sugar adds; among those drinking more than three cups of instant coffee, older adults, men, and current smokers showed greater age-acceleration in some measures.

via News-Medical|

#aging #coffee #health

health3 months ago•8 min saved

Move More, Age Less: Exercise Targets All 14 Hallmarks of Aging

Regular exercise can modulate all 14 hallmarks of ageing identified in a scientific review, improving genome stability, telomere maintenance, epigenetic regulation, proteostasis, autophagy, mitochondria, intercellular communication and inflammation among others; the lifestyle benefits are echoed by findings that 7,000 daily steps cut all-cause mortality by ~47% and strength training may add up to four years of life.

via HuffPost UK|

#aging #autophagy #exercise

science3 months ago•85 min saved

Telomeric DDR blockade rejuvenates aging hematopoiesis

Therapeutic inhibition of telomeric DNA damage response using telomeric antisense oligonucleotides (tASO) suppresses tDDR signaling in telomerase-deficient mice and physiologically aged mice, reducing cellular senescence and inflammation, restoring hematopoietic tissue architecture, enhancing hematopoietic stem/progenitor cell quiescence and fitness, and improving in vivo repopulation and humoral immune responses; ex vivo human aged CD34+ HSPCs also show improved clonogenic potential. Telomere length is unchanged, indicating relief of dysfunction via tDDR blockade rather than telomere elongation, suggesting tDDR inhibition as a therapeutic strategy for telomere biology disorders and age-related hematopoietic aging.

via Nature|

#hematopoietic-aging #hspcs #science

science4 months ago•3 min saved

Spaceflight Triggers Lasting Genetic Shifts in Human Twins

NASA's year-long twin study found spaceflight caused lasting genetic and physiological changes: about 7% of Scott Kelly's gene expression changed during flight, telomeres lengthened then shortened after return, and cognitive abilities declined; six months later, 811 genes remained differently expressed, underscoring potential safety needs for long missions and the need for more subjects to generalize results.

via bgr.com|

#genetics #nasa #science

science4 months ago•13 min saved

Spaceflight Leaves Lasting Molecular Footprints, Twin Study Reveals

NASA’s Scott–Mark Kelly twin study found no DNA sequence changes from a 340‑day mission, but about 7% of Scott’s gene expression remained dysregulated six months after landing. Telomeres lengthened in space and then shortened to below baseline upon return. Cognitive performance stayed slower for months; immune function, DNA repair, bone formation, hypoxia response, and mitochondrial pathways were affected, and liver metabolism shifted, suggesting spaceflight perturbs an interconnected biological network with lasting effects for future long-duration missions.

via Space Daily|

#gene-expression #mitochondria #science

science4 months ago•5 min saved

Melanoma Telomere Trick: Dual Mutations Drive Immortality

Researchers uncovered a two-part genetic strategy used by melanoma cells to bypass cellular aging: mutations that boost telomerase production via TERT and concurrent promoter mutations in ACD that recruit telomerase to telomeres through the shelterin component TPP1, lengthening chromosome caps and enabling extended cell division. This explains the unusually long telomeres seen in melanoma and points to a potential new therapeutic target.

via SciTechDaily|

#melanoma #science #telomerase

science5 months ago•6 min saved

Underwater 100-Day Experiment Sparks Aging-Reversal Claims

Biomedical engineer Joseph Dituri spent 100 days in a 22-foot-deep underwater habitat at 1.6 ATA, undergoing tests that found increased energy, lower cholesterol and inflammatory markers, and a sevenfold rise in testosterone, plus REM sleep gains and a temporary height loss from pressure. He argues daily hyperbaric oxygen therapy could shave 10 years off age, but scientists caution there is no robust evidence that such exposure extends life expectancy and some findings were misinterpreted. Dituri is now part of a larger 200-participant XPRIZE effort to study healthy lifespan extension.

via Indian Defence Review|

#aging #hyperbaric-oxygen-therapy #science

lifestyle6 months ago•18 min saved

Dark chocolate’s theobromine linked to slower aging in humans

A study of about 1,600 adults found higher blood levels of theobromine, a compound in cocoa, linked to slower biological aging markers—lower GrimAge acceleration and longer telomeres. The association persisted after adjusting for age, weight, smoking, and even caffeine, and appeared strongest among former smokers. The work is observational, so it cannot prove causation, and researchers emphasize diet quality over chasing a single nutrient. They note the potential that theobromine enhances cocoa’s polyphenols, and call for controlled trials to determine causality and practical guidance on dark‑chocolate consumption.

via Earth.com|

#aging #dark-chocolate #epigenetics

science7 months ago•7 min saved

Dick Van Dyke Turns 100, Crediting a Calm Outlook—And Science Seems to Agree

Dick Van Dyke recently turned 100 and attributes his longevity to a positive outlook and never getting angry; research cited alongside the piece links optimism and stress reduction to longer lifespans, discusses telomeres as a cellular aging factor, and notes that better anger management and healthy habits may contribute to longer, healthier aging.

via ScienceAlert|

#anger-management #dick-van-dyke #longevity

lifestyle7 months ago•17 min saved

Theobromine in chocolate could slow aging, study suggests

A King's College London study found higher blood theobromine levels, a compound in dark chocolate and coffee, are linked to slower biological aging markers (GrimAge and DNAmTL) in about 1,600 adults, even after accounting for caffeine; the signal is strongest among former-smokers and appears independent of caffeine. However, the study is observational and cannot prove causation, so researchers advocate focusing on overall diet quality rather than chasing a single nutrient, while noting dark chocolate’s sugar and fat content and the importance of modest portions.

via Earth.com|

#aging #chocolate #epigenetics