
Ancient Neanderthal Variant Promotes Extra Muscle in Some Modern Humans
A Neanderthal variant of the growth hormone receptor (GHR) in modern humans boosts growth hormone signaling, with cells showing ~40% faster growth after hormone exposure and carriers gaining about 270 g more muscle on average. The variant's frequency varies by population (rare in Europeans, higher in parts of South and East Asia; ~24% in a Pakistani cohort). The effect appears during puberty rather than birth, contributing to a stockier build but not fully explaining Neanderthal anatomy; nearby genetic differences may also influence the traits.













