Tag

Nanomedicine

All articles tagged with #nanomedicine

science26 days ago•3 min saved

Low-tech liposomes enable brain-penetrant chemotherapy after glioblastoma surgery

In a mouse model of glioblastoma, researchers loaded the chemotherapy drug doxorubicin into standard liposome nanoparticles and administered it soon after tumor resection. The temporary disruption of the blood-brain barrier allowed the liposome-encapsulated drug to accumulate at the tumor margin for up to 72 hours, with levels undetectable after seven days, suggesting a practical post-surgical delivery window and a potentially translatable, low-tech nanomedicine approach that could move toward human trials.

via Fierce Biotech|

#blood-brain-barrier #doxorubicin #glioblastoma

science5 months ago•5 min saved

Pig-semen–derived exosome eye drops halt retinal tumors in mice

A Science Advances study reports eye drops made from pig-semen–derived exosomes carrying a nanozyme cancer-killing system can cross the retinal barrier to target retinoblastoma tumors in mice, halting tumor growth and preserving vision; the approach uses folic-acid tagging to improve selectivity and could inform drug delivery across other hard-to-penetrate barriers, though it is currently at early, animal-tested stages.

via Nature|

#exosomes #nanomedicine #pig-semen

biomedicine5 months ago•12 min saved

Pancreas-targeted lipid nanoparticles enable RNA delivery

Nature News & Views highlights Lei et al.’s method for engineering lipid nanoparticles that specifically deliver therapeutic RNA to pancreatic cell populations in animals, addressing liver-biased distribution and enabling new avenues for treating currently incurable pancreatic diseases.

via Nature|

#biomedicine #lipid-nanoparticles #nanomedicine

science6 months ago•7 min saved

Engineered Liposomes Map Cancer Spread and Hint at Stopping It

Researchers are investigating how cancer uses extracellular vesicles to colonize new organs and are creating artificial liposomes that mimic these vesicles to observe uptake by cancer cells in real time, with the goal of delivering targeted therapies and ultimately blocking metastasis while improving drug delivery.

via ScienceAlert|

#drug-delivery #extracellular-vesicles #liposomes

science7 months ago•7 min saved

Dancing-molecule nanotherapy crosses the blood-brain barrier to repair stroke damage

Northwestern researchers have developed an injectable regenerative nanomaterial built from dynamic “dancing molecules” that can cross the blood-brain barrier after reperfusion in a mouse model of ischemic stroke. Delivered intravenously immediately after clot removal, the therapy reduced brain damage and inflammation without observed toxicity, suggesting it could complement clot-busting treatments. The approach relies on smaller peptide assemblies crossing the BBB before larger nanofibers form in brain tissue, and may have implications for traumatic brain injury and neurodegenerative diseases. Next steps include longer-term functional studies and exploring additional regenerative signals.

via SciTechDaily|

#blood-brain-barrier #nanomedicine #regenerative-medicine

health9 months ago•4 min saved

Nanotech Boosts Cancer Drug Potency 20,000x with No Side Effects

Researchers at Northwestern University have developed a nanotech-based reformulation of the chemotherapy drug 5-fluorouracil using spherical nucleic acids, making it 20,000 times more effective against leukemia cells with minimal side effects, potentially revolutionizing cancer treatment.

via ScienceDaily|

#cancer-treatment #chemotherapy #health

science9 months ago•5 min saved

Revolutionary Nanomedicine Eliminates Leukemia in Animal Studies

Northwestern University scientists have redesigned a traditional chemotherapy drug into a spherical nucleic acid, increasing its potency by 20,000 times and targeting leukemia cells more precisely with no detectable side effects in animal models, potentially revolutionizing cancer treatment.

via SciTechDaily|

#cancer #chemotherapy #drug-development

health-and-medicine10 months ago•48 min saved

Nanoparticle Therapy Reverses Alzheimer's in Mice

The article discusses a novel nanomedicine approach using mid-affinity, multivalent polymersomes targeting LRP1 to restore blood-brain barrier function, enhance amyloid-β clearance, and improve cognitive outcomes in Alzheimer's disease models, highlighting a shift from transport to repair strategies.

via Nature|

#alzheimers-disease #amyloid-b-clearance #blood-brain-barrier

science11 months ago•5 min saved

DNA-Wrapped Nanoparticles Tripling CRISPR Efficiency

Scientists at Northwestern University developed lipid nanoparticle spherical nucleic acids (LNP-SNAs) that significantly improve CRISPR delivery into cells, tripling gene-editing efficiency, reducing toxicity, and enhancing the potential for safer genetic medicines.

via ScienceDaily|

#crispr #drug-delivery #gene-editing

science11 months ago•5 min saved

CRISPR Efficiency Triples with DNA-Wrapped Nanoparticles in Lab Tests

Northwestern University researchers have developed DNA-wrapped lipid nanoparticle spherical nucleic acids (LNP-SNAs) that significantly enhance CRISPR delivery, increasing cell entry efficiency threefold, reducing toxicity, and improving gene editing success, paving the way for safer and more effective genetic medicines.

via Phys.org|

#crispr #dna #gene-editing

health-medicine2 years ago•3 min saved

"Promising Oral Insulin Delivery System Offers Needle-Free Life for Diabetics"

Scientists have developed a new form of oral insulin that can be taken as an alternative to syringes or insulin pumps, successfully testing it on animals and planning to begin human trials in 2025. The insulin is designed to be delivered to the liver using a specialized polymer that responds to blood sugar levels, offering more precise delivery and potentially reducing unwanted side effects. If successful, the oral insulin could provide a more convenient and effective option for diabetes management.

via Euronews|

#clinical-trials #diabetes #health-medicine

science-and-technology2 years ago•5 min saved

Unveiling a Hidden Housekeeping Process in Kidney Cells: A Groundbreaking Discovery

Scientists at the University of Texas at Dallas have discovered a unique "housekeeping" process in kidney cells that allows them to eject unwanted content, rejuvenating the cells and maintaining kidney health throughout one's lifetime. Unlike other organs that regenerate through cell division, kidney cells do not divide to create new cells. The newly identified self-renewal mechanism, which involves the extrusion of cellular contents, provides insights into how kidneys can stay healthy in the absence of injury or illness. Further research could lead to advancements in nanomedicine and early detection of kidney disease.

via SciTechDaily|

#health-management #kidney-cells #nanomedicine

science3 years ago•5 min saved

"Groundbreaking Study Reveals Kidney Cells' Remarkable Self-Renewal Abilities"

Researchers at the University of Texas at Dallas have discovered a unique "housekeeping" process in kidney cells that allows them to eliminate unwanted cellular contents and renew themselves without cell division. This self-renewal mechanism, which is different from how other tissues regenerate, helps explain the long-term health of kidneys. The discovery may have implications for nanomedicine and early detection of kidney disease. The researchers found that gold nanoparticles taken in by kidney cells are encased in lysosomes and other organelles, which are then extruded into vesicles that float off into the extracellular space. This process, called extrusion-mediated self-renewal, allows the cells to update themselves with fresh contents and function properly.

via Phys.org|

#cellular-regeneration #early-detection #kidney-cells