Tag

Senescence

All articles tagged with #senescence

science19 days ago•6 min saved

Sugary Signal: Fructose From Senescent Cancer Cells May Drive Ovarian Tumor Spread

A Nature Aging study shows fructose secreted by chemotherapy‑induced senescent ovarian cancer cells acts as a signaling molecule that reduces cell adhesion and promotes detachment and metastasis in cell cultures and mice; altering fructose metabolism blocked movement, and high-fructose intake worsened spread in animals, suggesting dietary fructose restriction and senolytic therapies could improve treatment outcomes—though findings are preclinical and not yet applicable to humans.

via ScienceAlert|

#cancer #fructose #metastasis

science1 month ago•90 min saved

Aged white matter harbors a reversible senescent DAM microglia state linked to GAL3 signaling

In naturally aged mice, hippocampal-adjacent white matter accumulates a microglial population that co-expresses senescence and disease-associated microglia (DAM) markers, notably GAL3/Lgals3, defining a white matter–exclusive SenBrain-DAM state enriched in fimbria. Spatial profiling across IMC, GeoMx DSP and CosMx SMI reveals multiple age-related trajectories from homeostatic microglia to DAM and senescent states, with GAL3+ cells marking a prominent age-excluded subset. Systemic senotherapeutics targeting p16 (AP20187) or BCL2 (venetoclax) reduce GAL3+ DAM markers, lower p16, and restore microglial organization and morphology toward a youthful pattern in aged fimbria, including reduced APOE+ GAL3+ cell density and altered microglia–fiber tract alignment. These findings suggest a partially reversible senescence–DAM microglial phenotype in aging white matter and highlight GAL3/Lgals3 as a potential biomarker and target to mitigate white matter–related cognitive decline.

via Nature|

#aging #dam #microglia

science3 months ago•4 min saved

DNA aptamers pinpoint aging cells, paving the way for targeted treatments

Researchers at Mayo Clinic used DNA aptamers to selectively bind proteins on senescent cells, tagging these 'zombie' cells in mouse tissues and enabling their identification amid healthy cells. The study suggests aptamers could become a cost-effective tool for detecting senescent cells and may eventually enable targeted therapies, though applicability to humans remains to be shown.

via ScienceDaily|

#aging #aptamers #biomarkers

science3 months ago•8 min saved

Cancer-fighting Strategy: Turning Iron-Heavy 'Zombie' Cells Against Their Tumors

Researchers uncovered a vulnerability in senescent “zombie” cells that accumulate in tumors and aging tissues: they rely on GPX4 to shield themselves from iron-driven ferroptosis. Blocking GPX4 with covalent inhibitors exposes these iron-loaded cells to ferroptotic death. In a screen of 10,000 compounds, four senolytics stood out, three targeting GPX4, and testing in three mouse cancer models showed reduced tumor size and improved survival, suggesting potential to combine this approach with chemotherapy or immunotherapy. Ongoing work will identify which cancers and patients are most likely to benefit and how this affects anti-tumor immunity.

via SciTechDaily|

#cancer-therapy #ferroptosis #gpx4

science4 months ago•38 min saved

Aging Is Evolution’s Blind Spot: Why We Don’t Stay Young Past 40

Humans age largely because natural selection acts strongest on traits that affect early-life reproduction; after the reproductive window, pressures weaken, allowing late-life deterioration to accumulate. The article frames aging as a byproduct of evolutionary trade-offs rather than an adaptation, explaining why longevity isn’t strongly selected for and how researchers are probing the molecular roots of aging and potential ways to extend healthy lifespan.

via Forbes|

#aging #biology #evolution

health-and-science1 year ago•4 min saved

Bloodstream as Pathway for Aging

Research from Korea University reveals that the protein ReHMGB1, secreted by senescent cells, can spread aging signals through the bloodstream, impairing tissue regeneration. Blocking ReHMGB1 in mice reduced aging markers and improved tissue repair, highlighting its potential as a target to combat age-related decline.

via Neuroscience News|

#aging #bloodstream #health-and-science

health-research2 years ago•4 min saved

"SARS-CoV-2 Induces Senescence in Dopamine Neurons"

A study reveals that SARS-CoV-2 can infect dopamine neurons in the brain, leading to senescence, which may contribute to neurological symptoms associated with long COVID. The infected neurons stop functioning and trigger inflammation, potentially impacting feelings of pleasure, motivation, and movement. The research suggests that certain drugs may prevent the virus's attack on the brain, and long COVID patients should be monitored for an increased risk of developing Parkinson's-related symptoms. This study was a collaboration between Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Columbia University Vagelos College of Physicians and Surgeons, and was supported by various grants from the National Institutes of Health.

via Weill Cornell Medicine Newsroom|

#dopamine-neurons #health-research #neurological-symptoms

science2 years ago•2 min saved

The Evolutionary Significance of Aging

New research suggests that aging and senescence, once considered inevitable consequences of life, may actually have an evolutionary advantage. A computer model developed by researchers in Hungary suggests that old age can be positively selected for in certain situations, where strong directional selection and significant kin selection are present. Aging and death may create space for a new generation with better gene compositions, and organisms that are strongly altruistic may benefit from having more generations sticking around through a drawn-out senescence. While the quest to stop aging continues, scientists are exploring the role of senescence in evolutionary advantage.

via ScienceAlert|

#aging #evolution #research

medical-research2 years ago•96 min saved

The Role of Iron Accumulation in Fibrosis and Senescence

Iron accumulation has been found to play a causative role in fibrogenesis, senescence, and the senescence-associated secretory phenotype (SASP). Fibrogenic injuries can lead to progressive iron accumulation in tissues, which promotes the secretion of pro-fibrotic cytokines, recruitment of immune cells, remodeling of the extracellular matrix, and activation of profibrogenic pathways. Iron accumulation also induces cellular senescence, characterized by the upregulation of senescence markers and DNA damage. These findings suggest that targeting iron accumulation may be a potential therapeutic strategy for fibrotic diseases.

via Nature.com|

#cellular-damage #fibrogenesis #fibrosis

science2 years ago•4 min saved

Senescence: A Catalyst for Evolutionary Acceleration, Scientists Discover

Scientists have used computer modeling to test the hypothesis that evolution can favor the proliferation of genes controlling senescence, or aging. The research suggests that under the right circumstances, aging can have an evolutionary function and be favored by natural selection. This finding challenges the classical non-adaptive theories of aging and opens up new possibilities for understanding the emergence and purpose of senescence in organisms.

via Phys.org|

#aging #computer-modeling #evolution

science3 years ago•4 min saved

"Revolutionary Discoveries: Sea Creature Challenges Aging Paradigms"

Researchers studying the regenerative capabilities of the sea creature Hydractinia symbiolongicarpus have discovered a link between healing and aging. The study found that senescence, typically associated with aging, plays a role in the creature's extreme regeneration abilities. The researchers identified a molecular signature associated with aging as the creature began regenerating new bodies. This finding suggests that the fundamental biological processes of healing and aging are intertwined. Understanding the regenerative abilities of organisms like Hydractinia could provide insights into human biology and advance the fields of regenerative medicine and age-related disease research.

via SciTechDaily|

#aging #hydractinia-symbiolongicarpus #regeneration

biology3 years ago•4 min saved

Unlocking the Secrets of Regeneration and Aging: The Key Lies in a Tiny Sea Creature

Researchers studying the regenerative abilities of the tiny sea creature Hydractinia symbiolongicarpus have discovered a molecular signature associated with aging, or senescence, during the process of regeneration. This finding suggests that healing and aging are intertwined biological processes. The study provides new insights into how aging evolved and highlights the potential for understanding human biology and developing regenerative medicine. Hydractinia's ability to regenerate and its unique stem cell system offer valuable insights into the origins of fundamental biological processes like aging and healing.

via News-Medical.Net|

#aging #biology #evolution

science3 years ago•4 min saved

"Unveiling the Secrets of Aging and Healing: Insights from a Squishy Sea Creature"

Scientists studying the small sea creature Hydractinia symbiolongicarpus have discovered that the processes of healing and aging are intertwined. The researchers found that as the creature regenerates its body, it exhibits a molecular signature associated with aging, or senescence. This finding challenges previous understanding of senescence in human cells and provides new insights into the evolution of aging and healing. The study also revealed that Hydractinia has the ability to eject senescent cells, a process not observed in humans. By studying these distant animal relatives, scientists hope to unravel the secrets of regeneration and aging, which could advance the fields of regenerative medicine and age-related disease research.

via National Institutes of Health (.gov)|

#aging #healing #hydractinia-symbiolongicarpus

science-and-technology3 years ago•4 min saved

Revolutionary Drug Delivery Method Reverses Stem Cell Senescence

Researchers have developed a new method of delivering antioxidants to stem cells that can prevent senescence, a process of cellular aging. The method utilizes polymer-stabilized crystals created through microfluidics, which ensures uniform size and dosage, minimizing variation in drug release between cells. The crystals dissolve at a slower rate, resulting in a uniform and extended release of the drug, increasing its effectiveness. This approach could improve the reproducibility of stem cell cultures and enhance the production of biomolecules for therapeutic use. The method has potential applications in biomanufacturing and could be used to deliver other drugs directly into target tissues.

via Phys.org|

#antioxidants #biomanufacturing #drug-delivery