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Stem Cells

All articles tagged with #stem cells

Lab-grown human sperm advances in mice, but full maturity remains elusive
science1 day ago

Lab-grown human sperm advances in mice, but full maturity remains elusive

Researchers transplanted human iPS-derived immature cells into a mouse kidney pouch, where they self-organized into early sperm-supporting structures and developed into spermatogonia after six months. While this marks progress toward lab-made sperm, the cells did not mature yet, signaling further hurdles. The work offers a new avenue to study early human sperm development and infertility, though clinical applications are far off and raise ethical questions about future reproductive technologies.

via Nature|
#bioethics#infertility#lab-grown-sperm
Lab-grown retinal vessels restore function in mice, fueling hope for blindness treatments
science5 days ago

Lab-grown retinal vessels restore function in mice, fueling hope for blindness treatments

Duke University researchers used induced pluripotent stem cells (iPSCs) to grow retinal endothelial cells—the vessels lining the retina—and demonstrated they can form functional vascular networks in lab conditions. When injected into mouse models of retinal disease, the lab-grown cells integrated with existing tissue to rebuild blood vessels and restore retinal function, suggesting a cheaper, scalable path toward preventative therapies for conditions like diabetic retinopathy.

via Good News Network|
#diabetic-retinopathy#ipscs#retina
Immunotherapy Sparks Hair Color Comeback, Hinting at Grey Hair Reversal
science9 days ago

Immunotherapy Sparks Hair Color Comeback, Hinting at Grey Hair Reversal

Emerging reports suggest grey hair might be reversible: cancer patients treated with immunotherapy drugs showed hair pigment returning, possibly by reactivating melanocyte stem cells. University of Alabama researchers are pursuing this for hair pigment, but no human trials exist yet, so practical applications are months away. Meanwhile, market supplements claim repigmentation with limited evidence.

via New York Post|
#greying-hair#hair-pigment#immunotherapy
Aging reveals a new fat-making stem cell driving belly fat growth
sciencehealth14 days ago

Aging reveals a new fat-making stem cell driving belly fat growth

City of Hope and UCLA researchers identify a middle-age–specific stem cell population called committed preadipocytes (CP-As) that arise from adipocyte progenitor cells and markedly generate new fat cells in the belly; the process is driven by LIFR signaling, with mouse experiments showing aged APCs produce many new fat cells, and similar CP-A–like cells found in human tissue, suggesting a potential target to curb age-related belly fat.

via ScienceDaily|
#adipose-tissue#aging#belly-fat
Immunotherapy Could Repaint Gray Hair, Early Research Finds
health19 days ago

Immunotherapy Could Repaint Gray Hair, Early Research Finds

New research suggests immunotherapy drugs that activate the immune system might reactivate pigment-producing stem cells in hair follicles to restore color and possibly reverse graying, inspired by reports that some cancer patients treated with immunotherapy experienced hair repigmentation; current evidence comes from cells and animal models, with no approved gray-hair reversal yet. More human studies are needed—if gray hair is a medical concern, consult a dermatologist.

via TODAY.com|
#gray-hair#hair-pigmentation#health
Electric Pulses Trigger Rejuvenation in Sea Squirts, Hinting at Human Anti-Aging Possibilities
science27 days ago

Electric Pulses Trigger Rejuvenation in Sea Squirts, Hinting at Human Anti-Aging Possibilities

Researchers delivered brief pacemaker-like electrical pulses to sea squirts, triggering an exercise-like surge in metabolism that improved stem cell activity, tissue growth, and even lifespan, with gene expression patterns resembling post-exercise responses; while promising, the findings are in a simple organism and their relevance to humans remains to be tested.

via bgr.com|
#aging#electric-stimulation#gene-expression
Period Blood Emerges as a Promising Medical Resource
science1 month ago

Period Blood Emerges as a Promising Medical Resource

New studies show menstrual fluid speeds skin wound healing, may enable noninvasive cervical cancer screening with high sensitivity, can help detect endometriosis with a simple test strip, and contains stem cells with regenerative potential for infertility and neurological conditions, suggesting period blood could become a valuable biomedical resource rather than waste.

via Upworthy|
#diagnostics#endometriosis#menstrual-blood
Orbital Blastoids Probe Early Human Development in Microgravity
space1 month ago

Orbital Blastoids Probe Early Human Development in Microgravity

China sent stem-cell–derived embryo models (blastoids) to the Tiangong space station to study how the earliest stages of human development behave in microgravity. The experiment includes peri-implantation and peri-gastrulation models cultured for five days and then frozen for Earth-based analysis, with a ground-control batch for comparison. While it cannot prove humans can reproduce in space—blastoids are not real embryos and five days is a small window—it will provide concrete data on whether early development can tolerate off-Earth conditions and guide future research and engineering needs.

via Space Daily|
#biology#embryology#microgravity
China Sends Lab-Grown Embryos to Space to Study Early Development in Orbit
space1 month ago

China Sends Lab-Grown Embryos to Space to Study Early Development in Orbit

China’s Tianzhou‑10 cargo mission delivered roughly 7 tons of supplies to the Tiangong space station and carried two types of living stem‑cell–based “artificial embryos” to study early human development in microgravity. Representing 14–21 days after fertilization, the peri‑implantation and peri‑gastrulation embryos will be grown for about five days in orbit, then frozen and returned to Earth for analysis to assess how space radiation and zero gravity affect embryo development—an important step for potential off‑Earth reproduction—though the researchers emphasize these are embryo‑like and not viable human embryos.

via Live Science|
#biology#china#embryology
Space-grown mini-hearts beat Earth labs in production speed, study finds
space-exploration2 months ago

Space-grown mini-hearts beat Earth labs in production speed, study finds

Researchers report that mini-hearts derived from human stem cells can be grown aboard the International Space Station at a far higher rate than on Earth, thanks to microgravity letting cells float freely without the need for aggressive stirring. This space-based production could yield thicker, more robust heart tissue and organoids for drug testing and potential future therapies, even as astronauts’ hearts undergo microgravity-induced changes. While space-grown tissues show promise and may eventually aid heart-disease research and transplants, human clinical use remains years away and further experiments—like on the SpaceX CRS-35 mission—are planned to scale and validate the approach.

via Space|
#heart-disease#international-space-station#nasa
Two Stem-Cell Pathways Could Enable Real Tooth and Jawbone Regrowth
science2 months ago

Two Stem-Cell Pathways Could Enable Real Tooth and Jawbone Regrowth

Researchers identified two distinct mesenchymal stem cell lineages that drive tooth root and surrounding bone formation in developing teeth. One lineage from the apical papilla uses CXCL12 and Wnt signaling to become odontoblasts, cementoblasts, or osteoblasts; the other lineage in the dental follicle (PTHrP-expressing) forms alveolar bone via a Hedgehog–Foxf–signaling interaction that must be suppressed to activate bone fate. Mapping these pathways provides a mechanistic framework for tooth-root development and could inform stem-cell–based therapies to regenerate teeth and periodontal bone.

via SciTechDaily|
#alveolar-bone#hedgehog-foxf-axis#science