Tag

Liquid Biopsy

All articles tagged with #liquid biopsy

health23 days ago•11 min saved

AI-Driven Blood Test Detects Liver Cancer Across Diverse Populations

Johns Hopkins researchers validated an AI-powered DELFI liquid biopsy that detects liver cancer across two geographically and biologically distinct populations (Guatemala and Romania). When combined with AFP and basic risk factors, the test identified both early- and late-stage cancers with greater sensitivity than current blood tests, by analyzing genome-wide DNA fragment patterns that reflect signals from tumor, liver cells, blood vessels, and immune responses. The study also noted region-specific molecular signatures (e.g., aflatoxin-associated patterns in Guatemala) while the overall classifier remained effective across cancer causes. Future work will include prospective validation and integrating fragmentome analysis with other biomarkers for even earlier detection.

via News-Medical|

#artificial-intelligence #cell-free-dna #fragmentome

biotechnology4 months ago•8 min saved

MethylScan: A Low-Cost Blood Test for Early, Multi-Disease Detection

UCLA researchers report MethylScan, a simple, affordable test that analyzes DNA methylation in circulating cell-free DNA to detect multiple cancers and liver diseases, and to indicate tissue of origin and organ health. In 1,061 samples, it achieved about 98% specificity, ~63% cancer detection across stages (~55% for early-stage) and ~80% detection of liver cancers in high‑risk groups, with a sequencing depth of ~300× costing under $20 per test as costs fall. By reducing background DNA, it functions as a system-wide health monitor, though larger prospective studies are needed to confirm real-world effectiveness.

via SciTechDaily|

#biotechnology #cancer-detection #cell-free-dna

health5 months ago•12 min saved

The bold promise of multi-cancer blood tests hits real-world limits

Multi-cancer early detection (MCED) blood tests, including Galleri, promise to detect dozens of cancers from one blood sample, but few have robust randomized trial data; the NHS-backed Galleri trial failed to show improved outcomes in reducing late-stage cancers, and while tests boast high specificity, sensitivity varies and the risk of false positives can lead to anxiety and unnecessary follow-ups, leaving regulators and clinicians cautious until stronger evidence accumulates.

via Nature|

#cancer-screening #galleri #health

science7 months ago•8 min saved

Cancer’s Hidden Barcode: OncRNA Signatures Map Tumor Identity and Treatment Response

Researchers mapped hundreds of thousands of cancer-specific small RNAs (oncRNAs) that act as digital barcodes to identify cancer type, subtype, and aggressiveness. Many oncRNAs are secreted into blood, enabling a simple serum test to monitor treatment response and predict survival. The work blended large-scale genome analysis, machine learning, mouse experiments, and data from nearly 200 breast cancer patients, finding about 5% of oncRNAs can drive tumor growth. The discovery points to a new, blood-based approach for real-time cancer monitoring and personalized therapy, with ongoing development in collaboration with Exai Bio.

via SciTechDaily|

#biomarkers #breast-cancer #cancer

health7 months ago•3 min saved

Blood test flags effective breast cancer therapies before treatment starts

A London study shows a simple liquid biopsy measuring circulating tumour DNA (ctDNA) in advanced breast cancer can predict treatment response before starting therapy and after one cycle. In 167 patients, lower ctDNA levels were associated with better outcomes, suggesting this test could guide personalized treatment and spare ineffective drugs, with trials exploring adaptive strategies and newer therapies.

via The Guardian|

#breast-cancer #circulating-tumour-dna #ctdna

health8 months ago•7 min saved

Advances in Blood Tests Promise Early Detection and Improved Cancer Outcomes

New blood tests capable of detecting multiple cancers simultaneously show promise for earlier diagnosis and improved cancer care, but currently face challenges such as high false-positive rates, lack of standardization, and integration into clinical practice. Experts believe these tests will improve over time and could revolutionize cancer diagnostics, though more research and validation are needed.

via Live Science|

#cancer-detection #early-diagnosis #false-positives

health10 months ago•1 min saved

Innovative Blood Test Detects Head and Neck Cancer a Decade Early

A new blood test called HPV-DeepSeek, developed by Mass General Brigham, can detect HPV-associated head and neck cancer up to 10 years before clinical diagnosis with 99% accuracy, using advanced genome sequencing and machine learning to identify circulating tumor DNA in blood samples.

via Times of India|

#blood-test #cancer-detection #early-diagnosis

health10 months ago•4 min saved

Early Blood Test Detects Head and Neck Cancer a Decade Before Symptoms

A new blood test called HPV-DeepSeek can detect HPV-related head and neck cancers up to 10 years before symptoms appear, potentially enabling earlier treatment and better outcomes.

via SciTechDaily|

#blood-test #early-detection #head-and-neck-cancer

health11 months ago•2 min saved

Tears Offer Hope for Early Brain Tumour Detection

A man with an incurable brain tumor has donated his tears to a pioneering study exploring tear fluid as a non-invasive method for early brain cancer detection, potentially leading to faster diagnoses and improved outcomes.

via BBC|

#brain-tumor #cancer-research #early-diagnosis

health11 months ago•3 min saved

Innovative Blood Test Detects HPV-Related Head and Neck Cancers a Decade Early

A new blood test called HPV-DeepSeek can detect HPV-associated head and neck cancers up to 10 years before symptoms appear, potentially enabling earlier treatment and better outcomes.

via Medical Xpress|

#early-detection #head-and-neck-cancer #health

health1 year ago•3 min saved

Revolutionary Blood Tests Transforming Cancer Detection and Care in the NHS

Scientists highlight that small health issues like persistent cough, breathlessness, and unexplained weight loss can be early signs of lung cancer. NHS England is introducing a groundbreaking liquid biopsy blood test for faster, personalized cancer diagnosis, initially for lung and breast cancers, which could significantly improve early detection and treatment outcomes.

via The Independent|

#cancer-treatment #early-detection #health

health1 year ago•6 min saved

NHS introduces groundbreaking blood test to revolutionize cancer diagnosis and treatment

NHS England is pioneering the global rollout of a revolutionary blood test called liquid biopsy for lung and breast cancer patients, enabling faster, more targeted treatment and potentially saving up to £11 million annually, while improving patient outcomes and reducing invasive procedures.

via NHS England|

#cancer-diagnosis #health #liquid-biopsy

health1 year ago•2 min saved

Breakthrough Blood Test Revolutionizes Rapid Cancer Detection

Researchers at the University of Rochester have developed a new method called "catch and display for liquid biopsy" (CAD-LB) that uses ultrathin membranes to capture extracellular vesicles (EVs) from a single drop of blood. This method simplifies the process of identifying EVs, which carry important biomarkers, making it faster and more cost-effective for cancer diagnosis and monitoring treatment progress. The technique also shows potential for detecting immune proteins, aiding in the selection of personalized immunotherapies.

via SciTechDaily|

#biomedical-engineering #cancer #diagnostics

health2 years ago•2 min saved

"New Blood Test Achieves 100% Accuracy in Predicting Breast Cancer Relapse"

A new ultra-sensitive blood test developed by researchers at the Institute of Cancer Research in London can predict the recurrence of breast cancer years before it appears on scans, with 100% accuracy. The test detects circulating tumor DNA (ctDNA) using whole genome sequencing, identifying up to 1,800 mutations. This breakthrough could enable earlier treatment and better long-term monitoring for patients at high risk of relapse.

via The Independent|

#blood-test #breast-cancer #cancer-research

health2 years ago•3 min saved

"Breakthrough Blood Test Predicts Breast Cancer Recurrence with 100% Accuracy"

A new blood test using whole genome sequencing can predict the risk of breast cancer returning up to three years before tumors appear on scans. This breakthrough, presented at the American Society of Clinical Oncology annual meeting, could help identify which women need preventive therapy and improve early treatment, significantly increasing the chances of beating the disease. Researchers found the test to be highly sensitive, accurately predicting relapse in all trial patients who later experienced recurrence.

via The Guardian|

#breast-cancer #cancer-recurrence #early-detection