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Personalized Medicine

All articles tagged with #personalized medicine

Intismeran phase 3 win accelerates personalized cancer vaccine momentum
business27 days ago

Intismeran phase 3 win accelerates personalized cancer vaccine momentum

Merck and Moderna announced that the intismeran (mRNA-4157) adjuvant vaccine, when combined with Keytruda, improved recurrence-free survival and distant metastasis-free survival in a phase 3 melanoma trial, renewing optimism for personalized neoantigen vaccines and potentially reshaping oncology if data readouts support broader use; regulators will be engaged for potential approvals, and the news spurred biotech stock gains while highlighting a growing field of mRNA cancer therapies from Arcturus, BioNTech, Strand Therapeutics and others.

via Fierce Biotech|
#business#immunotherapy#intismeran
Young-Onset Colorectal Cancer With Liver-Only Metastases Shows Distinct Biology and Survival Advantage
medical-research1 month ago

Young-Onset Colorectal Cancer With Liver-Only Metastases Shows Distinct Biology and Survival Advantage

A real-world study of 1,691 Australians with colorectal cancer that spread only to the liver found that patients diagnosed at age 50 or younger have distinct tumor biology and clinical features (including left-sided tumors and different mutation patterns) and tended to survive longer after liver metastasis than older patients. Across ages, BRAF and KRAS mutations were linked to poorer outcomes. Surgery to remove liver tumors followed by systemic therapy was associated with better survival, though causality can’t be proven from observational data. The findings support biology-informed, personalized treatment decisions that consider more than just age.

via news-medical.net|
#braf-mutations#early-onset-colorectal-cancer#kras-mutations
Hidden Onset: Barrett's Esophagus Likely Begins in Early Adulthood
health1 month ago

Hidden Onset: Barrett's Esophagus Likely Begins in Early Adulthood

Researchers using an esophagus-specific epigenetic clock analyzed UK cohorts and estimate that Barrett's esophagus often begins in early adulthood (roughly ages 20–30), decades before clinical diagnosis, creating a long premalignant window that may accumulate cancer-driving mutations and suggesting a shift toward personalized, continuous-risk screening rather than strict age cutoffs; however, broad screening of all GERD patients could lead to oversurveillance.

via Medscape|
#barretts-esophagus#epigenetic-clock#esophageal-adenocarcinoma
IL-10 Autoantibodies May Drive Inflammatory Bowel Disease in a Subset of Patients
science3 months ago

IL-10 Autoantibodies May Drive Inflammatory Bowel Disease in a Subset of Patients

A 2026 NEJM study analyzing data from more than 4,900 people with inflammatory bowel disease found that about 3.5% carry autoantibodies that block interleukin-10, effectively removing an anti-inflammatory brake and potentially driving disease in this subset; the autoantibibody presence is linked to the HLA-DRB1*01:03 variant, suggesting possibilities for early genetic testing and more targeted, mechanism-based therapies.

via Live Science|
#autoantibodies#hla-drb10103#inflammatory-bowel-disease
Personalized digital twins forecast lung fate during ex vivo perfusion
technology3 months ago

Personalized digital twins forecast lung fate during ex vivo perfusion

Researchers analyzed data from nearly 1,000 EVLP procedures to train a hybrid physics-ML model that creates a dynamic digital twin of a lung, enabling time-resolved predictions of 75+ functional and molecular parameters and early updates as new data arrive. The twin serves as a personalized control to predict no-treatment trajectories, allowing comparison with actual therapy (e.g., alteplase) to assess responses while reducing reliance on matched organs and mitigating inter-organ variability in preclinical transplantation studies.

via Nature|
#digital-twin#ex-vivo-lung-perfusion#hybrid-modeling
Gene test could spare many breast cancer patients from chemotherapy
health4 months ago

Gene test could spare many breast cancer patients from chemotherapy

An international trial found the Prosigna gene test can identify early breast cancer patients who can forgo chemotherapy, sparing about two-thirds of participants to receive hormone therapy alone; five-year survival was 93.7% without chemo versus 94.9% with chemo, suggesting broader adoption could save NHS patients thousands of chemotherapy sessions annually, though results for under-40s remain uncertain.

via BBC|
#breast-cancer#chemotherapy#clinical-trial
Genomic test could spare millions of breast cancer patients from chemotherapy
health4 months ago

Genomic test could spare millions of breast cancer patients from chemotherapy

The Optima trial, involving over 4,000 women with hormone-positive breast cancer, used the Prosigna genomic test to guide treatment. Women with low genomic risk received hormone therapy alone, while high-risk patients still received chemotherapy; at five years, survival and cancer-free rates were nearly identical (95% vs 94%), suggesting many could safely skip chemotherapy and reduce toxicity, heralding more personalized care.

via The Guardian|
#breast-cancer#chemotherapy#genomics
AI-Guided Mood Plan Yields 55% Depression Remission in Trial
health-technology4 months ago

AI-Guided Mood Plan Yields 55% Depression Remission in Trial

UC San Diego researchers used two weeks of smartwatch data and EMA mood logs to train a personalized machine‑learning model that identifies each participant’s top mood drivers and pairs them with tailored, remote coaching to create an individualized Mood Augmentation Plan (iMAP). Over six weeks, 55% of participants showed depression remission on PHQ-9, anxiety decreased 36%, and benefits persisted for three months post-intervention, suggesting a scalable, data‑driven approach to personalized depression care.

via Neuroscience News|
#depression#digital-health#health-technology
The Pace of Poop Could Shape Your Health, New Analysis Finds
science5 months ago

The Pace of Poop Could Shape Your Health, New Analysis Finds

A 2023 review of data from thousands of participants links how long stool spends in the gut to distinct microbiome profiles and health outcomes. Faster transit tends to favor carbohydrate-digesting bacteria, slower transit favors protein-utilizing microbes, and both extremes show reduced microbial diversity. Incorporating transit time improves predictions of gut microbiota beyond diet alone and could influence responses to probiotics and treatments, highlighting potential for personalized diet and therapy based on an individual’s gut rhythm.

via ScienceAlert|
#diet-microbiota-interactions#gut-microbiome#gut-transit-time
Smartwatch data plus routine labs power scalable insulin-resistance screening
healthcare6 months ago

Smartwatch data plus routine labs power scalable insulin-resistance screening

The WEAR-ME study (n=1,165) shows that combining wearable time-series data with demographics and routine blood biomarkers can predict insulin resistance (HOMA-IR ≥2.9) with AUROC around 0.80. Using a wearable foundation model to derive richer representations further improves performance, achieving AUROC ~0.82 in cross-validation, and up to ~0.88 when fasting glucose and a lipid/metabolic panel are included. An independent validation cohort confirms gains with wearable data, and an LLM-based insulin-resistance literacy agent is demonstrated to contextualize results and provide personalized guidance. The work proposes a scalable, noninvasive screening approach to identify at-risk individuals for early lifestyle interventions to prevent type 2 diabetes, while noting limitations in data missingness, generalizability, and the need for longitudinal validation.

via Nature|
#foundation-model#healthcare#homa-ir
Your body’s digital twin could guide highly personalized surgery
health7 months ago

Your body’s digital twin could guide highly personalized surgery

Live Science interviews Dr. John Pandolfino about a 400‑person clinical trial using a mechanically accurate digital twin of the esophagus to predict the best myotomy approach for achalasia and reduce complications like diverticulum. The virtual model guides surgical decisions, could lessen or replace some animal testing, and may eventually be extended to other organs such as the heart and bladder, though a fully comprehensive, molecular‑level digital twin remains a longer‑term goal.

via Live Science|
#achalasia#digital-twins#esophagus