Tag

Skeletal Muscle

All articles tagged with #skeletal muscle

science1 hour ago•8 min saved

Long COVID and ME/CFS drive distinct skeletal muscle changes beyond bed-rest effects

60-day bed rest in healthy adults causes muscle atrophy and altered maximal exercise responses without changing fiber type, whereas long COVID and ME/CFS patients show more glycolytic fibers (with ME/CFS showing type I–specific atrophy); oxidative phosphorylation capacity only links to maximal oxygen uptake after bed rest, indicating that inactivity alone cannot explain the reduced exercise capacity in these patients, suggesting disease-specific skeletal muscle remodeling.

via Nature|

#bed-rest #long-covid #mecfs

science2 months ago•37 min saved

Vitamin B12: fueling aging muscles by reviving mitochondrial energy

New Cornell-led research shows that even modest Vitamin B12 shortfalls can degrade aging muscle energy by harming mitochondria: B12 deficiency reduces mitochondrial DNA integrity and respiratory capacity, while short-term B12 supplementation in older mice doubled mitochondrial complex IV activity and boosted energy, suggesting blood B12 levels could guide precision nutrition to counter age-related muscle decline.

via Earth.com|

#aging #mitochondria #nutrition

medical-research9 months ago•2 min saved

Scientists Develop Drug to Counteract Cancer-Related Wasting

Research identifies RNA expression patterns linked to cachexia, a severe weight-loss syndrome associated with cancer that involves skeletal muscle wasting and is resistant to nutritional interventions, potentially leading to new treatment targets.

via Nature|

#cachexia #cancer #medical-research

health2 years ago•3 min saved

"Unveiling the Atlas of Aging: Understanding and Combatting Muscle Weakness"

Researchers have created the first comprehensive atlas of aging muscles in humans, shedding light on the cellular and molecular changes that occur with aging. The study reveals new cell populations and compensatory mechanisms that muscles employ to combat aging, offering potential avenues for future therapies and interventions to improve muscle health and quality of life as we age. The findings provide valuable insights into healthy skeletal muscle aging and have the potential to inform strategies for promoting healthier aging in future generations.

via Medical Xpress|

#aging-process #cellular-and-molecular-level #health

science-and-technology2 years ago•4 min saved

Revolutionary Stem Cell Research Promises Muscle Regeneration

Researchers at UCLA have made progress in developing stem cell therapies for regenerating skeletal muscle in humans. By transplanting lab-grown muscle stem cells into mice, they discovered the importance of the stem cell "niche" in supporting the survival and function of the cells. Removing existing stem cells and optimizing the muscle niche allowed the transplanted cells to persist and repair muscle injuries. The study highlights the need to optimize both the muscle niche and the muscle progenitor cells themselves for successful stem cell therapies in the future.

via Phys.org|

#lab-grown-cells #muscle-regeneration #science-and-technology

medical-science-news2 years ago•3 min saved

Unveiling the Crucial Role of Musashi-2 Protein in Muscle Regulation and Development

Researchers from Tokyo Metropolitan University have discovered that the protein Musashi-2 (Msi2) plays a crucial role in regulating muscle mass and metabolic processes in skeletal muscle. By studying mice with the Msi2 gene knocked out, they found a decrease in muscle mass due to a reduction in type 2a muscle fibers, as well as decreased myoglobin and mitochondria. Understanding the regulation of type 2a fibers could lead to new therapies for muscle-related conditions and improve training regimens for muscle strength.

via News-Medical.Net|

#medical-science-news #metabolic-processes #musashi-2-protein

health3 years ago•3 min saved

The Mysterious Link Between Cold Exposure and Metabolism

New research challenges the prevailing belief that brown adipose tissue (BAT) is responsible for the metabolic benefits of cold exposure. A team of Canadian researchers argues that skeletal muscles, not BAT, are the primary heat generator and drive the metabolism of glucose and lipids in cold temperatures. While BAT has been linked to lower body mass indices and improved metabolic health, it is only detectable in a small percentage of adults even in cold conditions. The researchers suggest that a more integrated perspective is needed, focusing on skeletal muscles as the main organ involved in heat production and energy expenditure during cold exposure. Further research is required to understand the full impact of cold exposure on metabolism and overall health.

via ScienceAlert|

#brown-adipose-tissue #cold-exposure #health